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Even if cysteine S -conjugate -lyase is responsible for the synthesis of the highly reactive and cytotoxic thiol version of cisplatin ( Figure 1 ), the activation of cisplatin into a nephrotoxin relies on the three previous steps of the classical mercapturic acid pathway involving GSTs (GSH conjugation), GT (production of CisPt-cys-glu) and dipeptidase (production of CisPt-cys

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As noted by the authors, there is no established reference range for TRX-1 levels in the neonates

These compounds, due to their ability to counteract ROS-induced pathways, hold promise in mitigating the damage sustained by TMCs and RGCs in glaucoma